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Jonny was here can you take benadryl while taking ibuprofen The next step will be to calibrate how much drug is needed to block the glutamate receptor in question â normal human brains need glutamate for almost every excitatory response â so completely shutting down its activity isnât feasible. But having another way to nip at the amyloid plaques in Alzheimerâs is a welcome advance â and could turn the tide of battle against the disease for millions of patients in coming decades.